Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Up-regulation of neural and cell cycle-related microRNAs in brain of amyotrophic lateral sclerosis mice at late disease stage

27 Jan 2015

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective motor neuron degeneration in motor cortex, brainstem and spinal cord. microRNAs (miRNAs) are small non-coding RNAs that bind complementary target sequences and modulate gene expression; they are key molecules for establishing a neuronal phenotype, and in neurodegeneration. Here we investigated neural...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to MicroRNA in disease regulation
Share to Neurogenetic and Muscular Disorders Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25626686
DOI: 10.1186/s13041-015-0095-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Up-regulation of neural and cell cycle-related microRNAs in brain of amyotrophic lateral sclerosis mice at late disease stagePMID 25626686Read ↗

Expression Changes of miRNAs in Humans and Animal Models of Amyotrophic Lateral Sclerosis and Their Potential Application for Clinical DiagnosisSemantic proximity Read ↗

MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS ModelsSemantic proximity Read ↗

miRNA-9 expression is upregulated in the spinal cord of G93A-SOD1 transgenic mice.Semantic proximity Read ↗

Increased Expression of MicroRNA-29a in ALS Mice: Functional Analysis of Its InhibitionSemantic proximity Read ↗

miRNA malfunction causes spinal motor neuron diseaseSemantic proximity Read ↗

miR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosisSemantic proximity Read ↗

Brain-specific knockdown of miR-29 results in neuronal cell death and ataxia in mice.Semantic proximity Read ↗

Aberrant microRNA expression in the brains of neurodegenerative diseases: miR‐29a decreased in Alzheimer disease brains targets neurone navigator 3Semantic proximity Read ↗

MicroRNAs in Cerebrospinal Fluid as Potential Biomarkers for Parkinson’s Disease and Multiple System AtrophySemantic proximity Read ↗

Analysis of the expression of mir-34a, mir-199a, mir-30c and mir-19a in peripheral blood CD4+T lymphocytes of relapsing-remitting multiple sclerosis patientsSemantic proximity Read ↗

Downregulation of MicroRNA-193b-3p Promotes Autophagy and Cell Survival by Targeting TSC1/mTOR Signaling in NSC-34 CellsSemantic proximity Read ↗

Micro RNA association with synucleinopathy conversion in rapid eye movement behavior disorderSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.