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Article

<i>OASIS/CREB3L1</i>is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration<i>in vitro</i>

2 Dec 2014

Abstract excerpt

CREB3L1 has been recently proposed as a novel metastasis suppressor gene in breast cancer. Our current study highlights CREB3L1 expression, regulation, and function in bladder cancer. We demonstrate a significant downregulation of CREB3L1 mRNA expression (n = 64) in primary bladder cancer tissues caused by tumor-specific CREB3L1 promoter hypermethylation (n = 51). Based on pyrosequencing CREB3L1 methylation was...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 25625847
DOI: 10.4161/15592294.2014.988052

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