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Article

Bone-marrow-derived very small embryonic-like stem cells in patients with critical leg ischaemia: evidence of vasculogenic potential.

Thrombosis and haemostasis - 1 May 2015

Guerin Coralie L, Loyer Xavier, Vilar José, Cras Audrey, Mirault Tristan, Gaussem Pascale, Silvestre Jean-Sébastien, Smadja David M

Abstract excerpt

Very small embryonic-like stem cells (VSELs) are multipotent stem cells localised in adult bone marrow (BM) that may be mobilised into peripheral blood (PB) in response to tissue injury. We aimed to quantify VSELs in BM and PB of patients with critical limb ischaemia (CLI) and to test their angiogenic potential in vitro as well as their therapeutic capacity in mouse model of CLI. We isolated BM VSELs from...

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Identifiers

PMID: 25608764
DOI: 10.1160/TH14-09-0748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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