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Article

Spatial variation of the colonic microbiota in patients with ulcerative colitis and control volunteers

16 Jan 2015

Abstract excerpt

OBJECTIVES: The relevance of spatial composition in the microbial changes associated with UC is unclear. We coupled luminal brush samples, mucosal biopsies and laser capture microdissection with deep sequencing of the gut microbiota to develop an integrated spatial assessment of the microbial community in controls and UC. DESIGN: A total of 98 samples were sequenced to a mean depth of 31,642 reads from nine...

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PMID: 25596182
DOI: 10.1136/gutjnl-2014-307873

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