Article
Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus.
Proceedings of the National Academy of Sciences of the United States of America - 13 Jan 2015
Pu Juan, Wang Shuoguo, Yin Yanbo, Zhang Guozhong, Carter Robert A, Wang Jinliang, Xu Guanlong, Sun Honglei, Wang Min, Wen Chu, Wei Yandi, Wang Dongdong, Zhu Baoli, Lemmon Gordon, Jiao Yuannian, Duan Susu, Wang Qian, Du Qian, Sun Meng, Bao Jinnan, Sun Yipeng, Zhao Jixun, Zhang Hui, Wu Gang, Liu Jinhua, Webster Robert G
Abstract excerpt
The emergence of human infection with a novel H7N9 influenza virus in China raises a pandemic concern. Chicken H9N2 viruses provided all six of the novel reassortant's internal genes. However, it is not fully understood how the prevalence and evolution of these H9N2 chicken viruses facilitated the genesis of the novel H7N9 viruses. Here we show that over more than 10 y of cocirculation of multiple H9N2 genotypes,...
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