Article
A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2015
Robbins Paul F, Kassim Sadik H, Tran Thai L N, Crystal Jessica S, Morgan Richard A, Feldman Steven A, Yang James C, Dudley Mark E, Wunderlich John R, Sherry Richard M, Kammula Udai S, Hughes Marybeth S, Restifo Nicholas P, Raffeld Mark, Lee Chyi-Chia R, Li Yong F, El-Gamil Mona, Rosenberg Steven A
Abstract excerpt
PURPOSE: Although adoptive cell therapy can be highly effective for the treatment of patients with melanoma, the application of this approach to the treatment of other solid tumors has been limited. The observation that the cancer germline (CG) antigen NY-ESO-1 is expressed in 70% to 80% and in a...
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