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Article

HIV-1 viral infectivity factor interacts with microtubule-associated protein light chain 3 and inhibits autophagy

8 Dec 2014

Abstract excerpt

OBJECTIVE: Autophagy, an important antiviral process triggered during HIV-1 entry by gp41-dependent membrane fusion, is repressed in infected CD4+ T cells by an unknown mechanism. The aim of this study was to identify the role of viral infectivity factor (Vif) in the autophagy blockade. DESIGN/METHODS: To determine the role of Vif in autophagy inhibition, we used cell lines that express CD4 and CXCR4 and primary...

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PMID: 25490467
DOI: 10.1097/qad.0000000000000554

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