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Article

FLAGS, frequently mutated genes in public exomes.

BMC medical genomics - 3 Dec 2014

Shyr Casper, Tarailo-Graovac Maja, Gottlieb Michael, Lee Jessica J Y, van Karnebeek Clara, Wasserman Wyeth W

Abstract excerpt

BACKGROUND: Dramatic improvements in DNA-sequencing technologies and computational analyses have led to wide use of whole exome sequencing (WES) to identify the genetic basis of Mendelian disorders. More than 180 novel rare-disease-causing genes with Mendelian inheritance patterns have been discovered through sequencing the exomes of just a few unrelated individuals or family members. As rare/novel genetic...

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Identifiers

PMID: 25466818
DOI: 10.1186/s12920-014-0064-y
PMCID: PMC4267152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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