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A Rare Human Syndrome Provides Genetic Evidence that WNT Signaling Is Required for Reprogramming of Fibroblasts to Induced Pluripotent Stem Cells

21 Nov 2014

Abstract excerpt

WNT signaling promotes the reprogramming of somatic cells to an induced pluripotent state. We provide genetic evidence that WNT signaling is a requisite step during the induction of pluripotency. Fibroblasts from individuals with focal dermal hypoplasia (FDH), a rare genetic syndrome caused by mutations in the essential WNT processing enzyme PORCN, fail to reprogram with standard methods. This blockade in...

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PMID: 25464842
DOI: 10.1016/j.celrep.2014.10.049

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Related research

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A Rare Human Syndrome Provides Genetic Evidence that WNT Signaling Is Required for Reprogramming of Fibroblasts to Induced Pluripotent Stem CellsPMID 25464842Read ↗

Deletion of mouse <i>Porcn</i> blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndromeSemantic proximity Read ↗

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PORCN mutations and variants identified in patients with focal dermal hypoplasia through diagnostic gene sequencing.Semantic proximity Read ↗

Multiple requirements of the focal dermal hypoplasia gene porcupine during ocular morphogenesis.Semantic proximity Read ↗

The Pleiotropic Effects of the Canonical Wnt Pathway in Early Development and PluripotencySemantic proximity Read ↗

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Goltz-Gorlin (focal dermal hypoplasia) and the microphthalmia with linear skin defects (MLS) syndrome: no evidence of genetic overlap.Semantic proximity Read ↗

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