Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Attenuation of monkeypox virus by deletion of genomic regions.

Virology - 15 Jan 2015

Lopera Juan G, Falendysz Elizabeth A, Rocke Tonie E, Osorio Jorge E

Abstract excerpt

Monkeypox virus (MPXV) is an emerging pathogen from Africa that causes disease similar to smallpox. Two clades with different geographic distributions and virulence have been described. Here, we utilized bioinformatic tools to identify genomic regions in MPXV containing multiple virulence genes and explored their roles in pathogenicity; two selected regions were then deleted singularly or in combination. In vitro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Viral
Share to Gene Expression Regulation, Viral
Share to Mice, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Real-Time Polymerase Chain Reaction

Share to Reassortant Viruses

Share to Viral Plaque Assay

Share to Virulence

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 25462353
DOI: 10.1016/j.virol.2014.11.009
PMCID: PMC4720520

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Attenuation of monkeypox virus by deletion of genomic regions.PMID 25462353Read ↗

Recent Advances in Research and Management of Human Monkeypox Virus: An Emerging Global Health ThreatSemantic proximity Read ↗

Monkeypox virus: The changing facets of a zoonotic pathogenSemantic proximity Read ↗

The Global Health Threat of Monkeypox Virus: Understanding Its Biology, Transmission, and Potential Therapeutic InterventionsSemantic proximity Read ↗

An overview on monkeypox virus: Pathogenesis, transmission, host interaction and therapeuticsSemantic proximity Read ↗

Insights into the monkeypox virus: Making of another pandemic within the pandemic?Semantic proximity Read ↗

Monkeypox: a re-emergent virus with global health implications – a comprehensive reviewSemantic proximity Read ↗

A tale of two clades: monkeypox virusesSemantic proximity Read ↗

Elucidating the Role of the Complement Control Protein in Monkeypox PathogenicitySemantic proximity Read ↗

Attenuation of the 2022 global outbreak monkeypox virus relative to its clade IIb ancestorSemantic proximity Read ↗

A systematic review on the global burden of human monkeypox: epidemiology and implications for outbreaksSemantic proximity Read ↗

Monkeypox virus: phylogenomics, host-pathogen interactome and mutational cascade.Semantic proximity Read ↗

Genomic Variability of Monkeypox Virus among Humans, Democratic Republic of the CongoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.