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Article

Elucidating the Role of the Complement Control Protein in Monkeypox Pathogenicity

9 Apr 2012

Abstract excerpt

Monkeypox virus (MPXV) causes a smallpox-like disease in humans. Clinical and epidemiological studies provide evidence of pathogenicity differences between two geographically distinct monkeypox virus clades: the West African and Congo Basin. Genomic analysis of strains from both clades identified a ∼10 kbp deletion in the less virulent West African isolates sequenced to date. One absent open reading frame encodes...

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PMID: 22496894
DOI: 10.1371/journal.pone.0035086

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