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Article

miR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3.

FEBS letters - 20 Dec 2014

Huang Fengzhen, Zhang Li, Long Zhe, Chen Zhao, Hou Xuan, Wang Chunrong, Peng Huirong, Wang Junling, Li Jiada, Duan Ranhui, Xia Kun, Chuang De-Maw, Tang Beisha, Jiang Hong

Abstract excerpt

MicroRNAs (miRNAs) have been reported to play significant roles in the pathogenesis of various polyQ diseases. This study aims to investigate the regulation of ATXN3 gene expression by miRNA. We found that miR-25 reduced both wild-type and polyQ-expanded mutant ataxin-3 protein levels by interacting with the 3'UTR of ATXN3 mRNA. miR-25 also increased cell viability, decreased early apoptosis, and downregulated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25451224
DOI: 10.1016/j.febslet.2014.11.013
PMCID: PMC6370487

Genes

ATXN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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