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Does degree of gyrification underlie the phenotypic and genetic associations between cortical surface area and cognitive ability?

NeuroImage - 1 Feb 2015

Docherty Anna R, Hagler Donald J, Panizzon Matthew S, Neale Michael C, Eyler Lisa T, Fennema-Notestine Christine, Franz Carol E, Jak Amy, Lyons Michael J, Rinker Daniel A, Thompson Wesley K, Tsuang Ming T, Dale Anders M, Kremen William S

Abstract excerpt

The phenotypic and genetic relationship between global cortical size and general cognitive ability (GCA) appears to be driven by surface area (SA) and not cortical thickness (CT). Gyrification (cortical folding) is an important property of the cortex that helps to increase SA within a finite space, and may also improve connectivity by reducing distance between regions. Hence, gyrification may be what underlies...

Topics

Cerebral Cortex
Cognition
Cognition Disorders
Genetic Association Studies
Humans
Male
Middle Aged
Morphogenesis
Organ Size
Phenotype

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PMID: 25433211
DOI: 10.1016/j.neuroimage.2014.11.040
PMCID: PMC4313767

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GCA

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