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Article

The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.

Molecular biology of the cell - 15 Jan 2015

Wang Ning, Wang Mo, Zhu Yi-Hua, Grosel Timothy W, Sun Daokun, Kudryashov Dmitri S, Wu Jian-Qiu

Abstract excerpt

Rho GTPases, activated by Rho guanine nucleotide exchange factors (GEFs), are conserved molecular switches for signal transductions that regulate diverse cellular processes, including cell polarization and cytokinesis. The fission yeast Schizosaccharomyces pombe has six Rho GTPases (Cdc42 and Rho1-Rho5) and seven Rho GEFs (Scd1, Rgf1-Rgf3, and Gef1-Gef3). The GEFs for Rho2-Rho5 have not been unequivocally...

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Identifiers

PMID: 25411334
DOI: 10.1091/mbc.E14-07-1196
PMCID: PMC4294672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.PMID 25411334Read ↗

The putative exchange factor Gef3p interacts with Rho3p GTPase and the septin ring during cytokinesis in fission yeast.Semantic proximity Read ↗

Rho1-GEFs Rgf1 and Rgf2 are involved in formation of cell wall and septum, while Rgf3 is involved in cytokinesis in fission yeast.Semantic proximity Read ↗

Schizosaccharomyces pombe Rgf3p is a specific Rho1 GEF that regulates cell wall beta-glucan biosynthesis through the GTPase Rho1p.Semantic proximity Read ↗

The small GTPase Rho4 is involved in controlling cell morphology and septation in fission yeast.Semantic proximity Read ↗

Novel Rho GTPase involved in cytokinesis and cell wall integrity in the fission yeast Schizosaccharomyces pombe.Semantic proximity Read ↗

Rho4 interaction with exocyst and septins regulates cell separation in fission yeast.Semantic proximity Read ↗

A Rho-type GTPase, rho-4, is required for septation in Neurospora crassa.Semantic proximity Read ↗

Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis.Semantic proximity Read ↗

Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis.Semantic proximity Read ↗

Rho4 GTPase is involved in secretion of glucanases during fission yeast cytokinesis.Semantic proximity Read ↗

The small GTPase Rho3 and the diaphanous/formin For3 function in polarized cell growth in fission yeast.Semantic proximity Read ↗

Cell wall remodeling at the fission yeast cell division site requires the Rho-GEF Rgf3p.Semantic proximity Read ↗

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