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Article

Rho1-GEFs Rgf1 and Rgf2 are involved in formation of cell wall and septum, while Rgf3 is involved in cytokinesis in fission yeast.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2005

Mutoh Tadashi, Nakano Kentaro, Mabuchi Issei

Abstract excerpt

The Rho GTPase acts as a binary molecular switch by converting between a GDP-bound inactive and a GTP-bound active conformational state. The guanine nucleotide exchange factors (GEFs) are critical activators of Rho. Rho1 has been shown to regulate actin cytoskeleton and cell wall synthesis in the fission yeast Schizosaccharomyces pombe. Here we studied function of fission yeast RhoGEFs, Rgf1, Rgf2, and Rgf3. It...

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Source

Identifiers

PMID: 16324155
DOI: 10.1111/j.1365-2443.2005.00908.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Rho1-GEFs Rgf1 and Rgf2 are involved in formation of cell wall and septum, while Rgf3 is involved in cytokinesis in fission yeast.PMID 16324155Read ↗

Cell wall remodeling at the fission yeast cell division site requires the Rho-GEF Rgf3p.Semantic proximity Read ↗

The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.Semantic proximity Read ↗

The small GTPase Rho4 is involved in controlling cell morphology and septation in fission yeast.Semantic proximity Read ↗

Schizosaccharomyces pombe Rgf3p is a specific Rho1 GEF that regulates cell wall beta-glucan biosynthesis through the GTPase Rho1p.Semantic proximity Read ↗

Rgf1p is a specific Rho1-GEF that coordinates cell polarization with cell wall biogenesis in fission yeast.Semantic proximity Read ↗

Novel Rho GTPase involved in cytokinesis and cell wall integrity in the fission yeast Schizosaccharomyces pombe.Semantic proximity Read ↗

The putative exchange factor Gef3p interacts with Rho3p GTPase and the septin ring during cytokinesis in fission yeast.Semantic proximity Read ↗

Rho4 GTPase is involved in secretion of glucanases during fission yeast cytokinesis.Semantic proximity Read ↗

Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis.Semantic proximity Read ↗

Mechanisms for concentrating Rho1 during cytokinesis.Semantic proximity Read ↗

Small GTPase Rho5 is a functional homologue of Rho1, which controls cell shape and septation in fission yeast.Semantic proximity Read ↗

Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis.Semantic proximity Read ↗

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