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Article

Prevention of skin carcinogenesis by the β-blocker carvedilol.

Cancer prevention research (Philadelphia, Pa.) - 1 Jan 2015

Chang Andy, Yeung Steven, Thakkar Arvind, Huang Kevin M, Liu Mandy M, Kanassatega Rhye-Samuel, Parsa Cyrus, Orlando Robert, Jackson Edwin K, Andresen Bradley T, Huang Ying

Abstract excerpt

The stress-related catecholamine hormones and the α- and β-adrenergic receptors (α- and β-AR) may affect carcinogenesis. The β-AR GRK/β-arrestin biased agonist carvedilol can induce β-AR-mediated transactivation of the EGFR. The initial purpose of this study was to determine whether carvedilol, through activation of EGFR, can promote cancer. Carvedilol failed to promote anchorage-independent growth of JB6 P(+)...

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Identifiers

PMID: 25367979
DOI: 10.1158/1940-6207.CAPR-14-0193
PMCID: PMC4289657

Genes

EGF
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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