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Article

Improved characterization of medically relevant fungi in the human respiratory tract using next-generation sequencing

24 Oct 2014

Abstract excerpt

BACKGROUND: Fungi are important pathogens but challenging to enumerate using next-generation sequencing because of low absolute abundance in many samples and high levels of fungal DNA from contaminating sources. RESULTS: Here, we analyze fungal lineages present in the human airway using an improved method for contamination filtering. We use DNA quantification data, which are routinely acquired during DNA library...

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PMID: 25344286
DOI: 10.1186/s13059-014-0487-y

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