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Network Analysis Identifies SOD2 mRNA as a Potential Biomarker for Parkinson's Disease

3 Oct 2014

Abstract excerpt

Increasing evidence indicates that Parkinson's disease (PD) and type 2 diabetes (T2DM) share dysregulated molecular networks. We identified 84 genes shared between PD and T2DM from curated disease-gene databases. Nitric oxide biosynthesis, lipid and carbohydrate metabolism, insulin secretion and inflammation were identified as common dysregulated pathways. A network prioritization approach was implemented to rank...

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PMID: 25279756
DOI: 10.1371/journal.pone.0109042

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