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Article

Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs.

Cell and tissue research - 1 Dec 2014

Rodriguez-Crespo David, Di Lauro Salvatore, Singh Amar K, Garcia-Gutierrez Maria T, Garrosa Manuel, Pastor J Carlos, Fernandez-Bueno Ivan, Srivastava Girish K

Abstract excerpt

Mesenchymal stem cell (MSC) therapy is promising for neuroprotection but there is no report of an appropriate in vitro model mimicking the situation of the in vivo retina that is able to test the effect of MSCs in suspension or encapsulated with/without a drug combination. This study aims to establish a viable mixed co-culture model having three layers: neuroretina explants (NRs), retinal pigment epithelium (RPE)...

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Source

Identifiers

PMID: 25213807
DOI: 10.1007/s00441-014-1987-5

Genes

RPE
MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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