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Article

GlialCAM, a CLC-2 Cl(-) channel subunit, activates the slow gate of CLC chloride channels.

Biophysical journal - 2 Sept 2014

Jeworutzki Elena, Lagostena Laura, Elorza-Vidal Xabier, López-Hernández Tania, Estévez Raúl, Pusch Michael

Abstract excerpt

GlialCAM, a glial cell adhesion molecule mutated in megalencephalic leukoencephalopathy with subcortical cysts, targets the CLC-2 Cl(-) channel to cell contacts in glia and activates CLC-2 currents in vitro and in vivo. We found that GlialCAM clusters all CLC channels at cell contacts in vitro and thus studied GlialCAM interaction with CLC channels to investigate the mechanism of functional activation. GlialCAM...

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Identifiers

PMID: 25185546
DOI: 10.1016/j.bpj.2014.07.040
PMCID: PMC4156679

Genes

CLC

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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GlialCAM, a CLC-2 Cl(-) channel subunit, activates the slow gate of CLC chloride channels.PMID 25185546Read ↗

GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit.Semantic proximity Read ↗

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