Article
Acquisition and evolution of SXT-R391 integrative conjugative elements in the seventh-pandemic Vibrio cholerae lineage.
mBio - 19 Aug 2014
Spagnoletti Matteo, Ceccarelli Daniela, Rieux Adrien, Fondi Marco, Taviani Elisa, Fani Renato, Colombo Mauro M, Colwell Rita R, Balloux François
Abstract excerpt
UNLABELLED: SXT-R391 Integrative conjugative elements (ICEs) are self-transmissible mobile genetic elements able to confer multidrug resistance and other adaptive features to bacterial hosts, including Vibrio cholerae, the causative agent of cholera. ICEs are arranged in a mosaic genetic structure composed of a conserved backbone interspersed with variable DNA clusters located in conserved hot spots. In this...
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