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Article

The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2014

Crisante Giovanna, Battista Laura, Iwaszkiewicz Justyna, Nesca Valeria, Mérillat Anne-Marie, Sergi Chloé, Zoete Vincent, Frateschi Simona, Hummler Edith

Abstract excerpt

Serine proteases, serine protease inhibitors, and protease-activated receptors (PARs) are responsible for several human skin disorders characterized by impaired epidermal permeability barrier function, desquamation, and inflammation. In this study, we addressed the consequences of a catalytically dead serine protease on epidermal homeostasis, the activation of PAR2 and the inhibition by the serine protease...

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Identifiers

PMID: 25138159
DOI: 10.1096/fj.14-253781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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