Article
A simple repeat polymorphism in the MITF-M promoter is a key regulator of white spotting in dogs.
PloS one - 1 Jan 2014
Baranowska Körberg Izabella, Sundström Elisabeth, Meadows Jennifer R S, Rosengren Pielberg Gerli, Gustafson Ulla, Hedhammar Åke, Karlsson Elinor K, Seddon Jennifer, Söderberg Arne, Vilà Carles, Zhang Xiaolan, Åkesson Mikael, Lindblad-Toh Kerstin, Andersson Göran, Andersson Leif
Abstract excerpt
The white spotting locus (S) in dogs is colocalized with the MITF (microphtalmia-associated transcription factor) gene. The phenotypic effects of the four S alleles range from solid colour (S) to extreme white spotting (s(w)). We have investigated four candidate mutations associated with the s(w) allele, a SINE insertion, a SNP at a conserved site and a simple repeat polymorphism all associated with the MITF-M...
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