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Article

Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA.

Nature - 14 Aug 2014

Huerta-Sánchez Emilia, Jin Xin, Asan, Bianba Zhuoma, Peter Benjamin M, Vinckenbosch Nicolas, Liang Yu, Yi Xin, He Mingze, Somel Mehmet, Ni Peixiang, Wang Bo, Ou Xiaohua, Huasang, Luosang Jiangbai, Cuo Zha Xi Ping, Li Kui, Gao Guoyi, Yin Ye, Wang Wei, Zhang Xiuqing, Xu Xun, Yang Huanming, Li Yingrui, Wang Jian, Wang Jun, Nielsen Rasmus

Abstract excerpt

As modern humans migrated out of Africa, they encountered many new environmental conditions, including greater temperature extremes, different pathogens and higher altitudes. These diverse environments are likely to have acted as agents of natural selection and to have led to local adaptations. One of the most celebrated examples in humans is the adaptation of Tibetans to the hypoxic environment of the...

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Identifiers

PMID: 25043035
DOI: 10.1038/nature13408
PMCID: PMC4134395

Genes

EPAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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