Article
Vitamin D receptor gene polymorphisms are associated with obesity and inflammosome activity.
PloS one - 1 Jan 2014
Al-Daghri Nasser M, Guerini Franca R, Al-Attas Omar S, Alokail Majed S, Alkharfy Khalid M, Draz Hossam M, Agliardi Cristina, Costa Andrea S, Saulle Irma, Mohammed Abdul Khader, Biasin Mara, Clerici Mario
Abstract excerpt
To explore the mechanisms underlying the suggested role of the vitamin D/vitamin D receptor (VDR) complex in the pathogenesis of obesity we performed genetic and immunologic analyses in obese and non-obese Saudi individuals without other concomitant chronic diseases. Genomic DNA was genotyped for gene single nucleotide polymorphisms (SNPs) of VDR by allelic discrimination in 402 obese (body mass index -BMI≥30...
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