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Article

MiR-221 accentuates IFN׳s anti-HCV effect by downregulating SOCS1 and SOCS3

12 Jul 2014

Abstract excerpt

MiR-221 was reported to be upregulated and play roles in tumorigenesis of hepatitis C virus (HCV) associated hepatocellular carcinoma (HCC). However, the role of miR-221 in HCV infection remains unknown. In this study, it was found that miR-221 was upregulated in serum of HCV chronic hepatitis patients and Huh7.5.1 cells infected with HCVcc. Further studies indicated that miR-221 mimic could accentuate anti-HCV...

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PMID: 25019494
DOI: 10.1016/j.virol.2014.06.024

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