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Article

<i>Plasmodium falciparum</i> transmission stages accumulate in the human bone marrow

9 Jul 2014

Abstract excerpt

Transmission of Plasmodium falciparum malaria parasites requires formation and development of gametocytes, yet all but the most mature of these sexual parasite forms are absent from the blood circulation. We performed a systematic organ survey in pediatric cases of fatal malaria to characterize the spatial dynamics of gametocyte development in the human host. Histological studies revealed a niche in the...

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PMID: 25009232
DOI: 10.1126/scitranslmed.3008882

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