Article
Is an integrative laboratory algorithm more effective in detecting alpha-1-antitrypsin deficiency in patients with premature chronic obstructive pulmonary disease than AAT concentration based screening approach?
Biochemia medica - 1 Jan 2014
Beletic Andjelo, Dudvarski-Ilic Aleksandra, Milenkovic Branislava, Nagorni-Obradovic Ljudmila, Ljujic Mila, Djordjevic Valentina, Mirkovic Dusko, Radojkovic Dragica, Majkic-Singh Nada
Abstract excerpt
INTRODUCTION: Alpha-1-antitrypsin deficiency (AATD), genetic risk factor for premature chronic obstructive pulmonary disease (COPD), often remains undetected. The aim of our study was to analyse the effectiveness of an integrative laboratory algorithm for AATD detection in patients diagnosed with COPD by the age of 45 years, in comparison with the screening approach based on AAT concentration measurement alone....
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