Article
Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort.
European heart journal - 7 Dec 2014
Masi Stefano, D'Aiuto Francesco, Martin-Ruiz Carmen, Kahn Tauseef, Wong Andrew, Ghosh Arjun K, Whincup Peter, Kuh Diana, Hughes Alan, von Zglinicki Thomas, Hardy Rebecca, Deanfield John Eric
Abstract excerpt
AIM: Cross-sectional studies reported associations between short leucocyte telomere length (LTL) and measures of vascular and cardiac damage. However, the contribution of LTL dynamics to the age-related process of cardiovascular (CV) remodelling remains unknown. In this study, we explored whether the rate of LTL shortening can predict CV phenotypes over 10-year follow-up and the influence of established CV risk...
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