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Article

Enzyme replacement therapy attenuates disease progression in a canine model of late-infantile neuronal ceroid lipofuscinosis (CLN2 disease).

Journal of neuroscience research - 1 Nov 2014

Katz Martin L, Coates Joan R, Sibigtroth Christine M, Taylor Jacob D, Carpentier Melissa, Young Whitney M, Wininger Fred A, Kennedy Derek, Vuillemenot Brian R, O'Neill Charles A

Abstract excerpt

Using a canine model of classical late-infantile neuronal ceroid lipofuscinosis (CLN2 disease), a study was conducted to evaluate the potential pharmacological activity of recombinant human tripeptidyl peptidase-1 (rhTPP1) enzyme replacement therapy administered directly to the cerebrospinal flui...

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Source

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Identifiers

PMID: 24938720
DOI: 10.1002/jnr.23423
PMCID: PMC4263309

Genes

TPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24938720-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Enzyme replacement therapy attenuates disease progression in a canine model of late-infantile neuronal ceroid lipofuscinosis (CLN2 disease).PMID 24938720Read ↗

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Clinical protocol. Administration of a replication-deficient adeno-associated virus gene transfer vector expressing the human CLN2 cDNA to the brain of children with late infantile neuronal ceroid lipofuscinosis.Semantic proximity Read ↗

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