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Article

Identification of new microRNAs targeting genes regulating the Pi/PPi balance in chondrocytes.

Bio-medical materials and engineering - 1 Jan 2014

Clement T, Salone V, Charpentier B, Jouzeau J-Y, Bianchi A

Abstract excerpt

Osteoarthritis (OA) is a whole-joint disease characterized by cartilage degradation and mineralization associated with chondrocyte phenotype changes, subchondral bone sclerosis and mild synovial inflammation. The extracellular levels of inorganic phosphate (ePi) and pyrophosphate (ePPi) are major regulators of the mineralization process but also play a role in the maintenance of the differentiated chondrocyte...

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PMID: 24928913
DOI: 10.3233/BME-140969

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