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Bluetongue virus without NS3/NS3a expression is not virulent and protects against virulent bluetongue virus challenge

10 Jun 2014

Abstract excerpt

Bluetongue is a disease in ruminants caused by the bluetongue virus (BTV), and is spread by Culicoides biting midges. Bluetongue outbreaks cause huge economic losses and death in sheep in several parts of the world. The most effective measure to control BTV is vaccination. However, both commercially available vaccines and recently developed vaccine candidates have several shortcomings. Therefore, we generated and...

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PMID: 24914064
DOI: 10.1099/vir.0.065615-0

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