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Article

β2 integrin mediates hantavirus-induced release of neutrophil extracellular traps

2 Jun 2014

Abstract excerpt

Rodent-borne hantaviruses are emerging human pathogens that cause severe human disease. The underlying mechanisms are not well understood, as hantaviruses replicate in endothelial and epithelial cells without causing any cytopathic effect. We demonstrate that hantaviruses strongly stimulated neutrophils to release neutrophil extracellular traps (NETs). Hantavirus infection induced high systemic levels of...

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PMID: 24889201
DOI: 10.1084/jem.20131092

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