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Current breast cancer proliferative markers correlate variably based on decoupled duration of cell cycle phases

30 May 2014

Abstract excerpt

Mitotic count, PhH3, and MIB-1 are used as measures of the proportion of proliferating malignant cells in surgical pathology. They highlight different stages of the cell cycle, but little is known about how this affects their counts. This study assesses the strength of their correlations and attempts to determine the relationship between them. Proliferation counts for forty-nine consecutive cases of invasive...

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PMID: 24874299
DOI: 10.1038/srep05122

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