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Skin-Resident T Cells Sense Ultraviolet Radiation–Induced Injury and Contribute to DNA Repair

8 May 2014

Abstract excerpt

Skin-resident T cells have been shown to play important roles in tissue homeostasis and wound repair, but their role in UV radiation (UVR)-mediated skin injury and subsequent tissue regeneration is less clear. In this study, we demonstrate that acute UVR rapidly activates skin-resident T cells in humans and dendritic epidermal γδ T cells (DETCs) in mice through mechanisms involving the release of ATP from...

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PMID: 24808367
DOI: 10.4049/jimmunol.1303297

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