Article
Clinical correlates and genetic linkage of social and communication difficulties in families with obsessive-compulsive disorder: Results from the OCD Collaborative Genetics Study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2014
Samuels Jack, Shugart Yin Yao, Wang Ying, Grados Marco A, Bienvenu O Joseph, Pinto Anthony, Rauch Scott L, Greenberg Benjamin D, Knowles James A, Fyer Abby J, Piacentini John, Pauls David L, Cullen Bernadette, Rasmussen Steven A, Stewart S Evelyn, Geller Dan A, Maher Brion S, Goes Fernando S, Murphy Dennis L, McCracken James T, Riddle Mark A, Nestadt Gerald
Abstract excerpt
Some individuals with obsessive-compulsive disorder (OCD) have autistic-like traits, including deficits in social and communication behaviors (pragmatics). The objective of this study was to determine if pragmatic impairment aggregates in OCD families and discriminates a clinically and genetically distinct subtype of OCD. We conducted clinical examinations on, and collected DNA samples from, 706 individuals with...
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