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Article

Does KRAS testing in metastatic colorectal cancer impact overall survival? A comparative effectiveness study in a population-based sample.

PloS one - 1 Jan 2014

Feigelson Heather Spencer, Zeng Chan, Pawloski Pamala A, Onitilo Adedayo A, Richards C Sue, Johnson Monique A, Kauffman Tia L, Webster Jennifer, Nyirenda Carsie, Alexander Gwen L, Hwang Clara, Cross Deanna, McCarty Catherine A, Davis Robert L, Schwarzkopf Denise, Williams Andrew E, Honda Stacey, Daida Yihe, Kushi Lawrence H, Delate Thomas, Goddard Katrina A B

Abstract excerpt

PURPOSE: Epidermal growth factor receptor (EGFR) inhibitors are approved for treating metastatic colorectal cancer (CRC); KRAS mutation testing is recommended prior to treatment. We conducted a non-inferiority analysis to examine whether KRAS testing has impacted survival in CRC patients. PATIENT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24788807
DOI: 10.1371/journal.pone.0094977
PMCID: PMC4006772

Genes

KRAS
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-24788807-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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