Multigene Analysis Unveils Distinctive Expression Profiles of Helper T-cell–related Genes in the Intestinal Mucosa that Discriminate Between Ulcerative Colitis and Crohnʼs Disease

Abstract excerpt

BACKGROUND: Although the involvement of helper T (Th) and regulatory T (Treg) cell-related immune molecules in pathogenesis of inflammatory bowel disease (IBD) is widely accepted, no discriminatory mucosal expression profiles of these molecules between ulcerative colitis (UC) and Crohn's disease (CD) have been clarified. METHODS: Mucosal expression of 17 cytokines and transcription factors related to Th1, Th2,...

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