Article
The WNT10A gene in ectodermal dysplasias and selective tooth agenesis.
American journal of medical genetics. Part A - 1 Oct 2014
Mues Gabriele, Bonds John, Xiang Lilin, Vieira Alexandre R, Seymen Figen, Klein Ophir, D'Souza Rena N
Abstract excerpt
Mutations in the WNT10A gene were first detected in the rare syndrome odonto-onycho-dermal dysplasia (OODD, OMIM257980) but have now also been found to cause about 35-50% of selective tooth agenesis (STHAG4, OMIM150400), a common disorder that mostly affects the permanent dentition. In our random sample of tooth agenesis patients, 40% had at least one mutation in the WNT10A gene. The WNT10A Phe228Ile variant...
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