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Article

Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulation

1 Apr 2014

Abstract excerpt

Regulation of SMN2 exon 7 splicing is crucial for the production of active SMN protein and the survival of Spinal Muscular Atrophy (SMA) patients. One of the most efficient activators of exon 7 inclusion is hnRNP G, which is recruited to the exon by Tra2-β1. We report that in addition to the C-terminal region of hnRNP G, the RNA Recognition Motif (RRM) and the middle part of the protein containing the Arg-Gly-Gly...

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PMID: 24692659
DOI: 10.1093/nar/gku244

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Characterization of the RNA recognition mode of hnRNP G extends its role in SMN2 splicing regulationPMID 24692659Read ↗

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Exclusion of Htra2-beta1, an up-regulator of full-length SMN2 transcript, as a modifying gene for spinal muscular atrophy.Semantic proximity Read ↗

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