Article
No association between vitamin D and β-cell autoimmunity in Finnish and Estonian children.
Diabetes/metabolism research and reviews - 1 Nov 2014
Reinert-Hartwall L, Honkanen J, Härkönen T, Ilonen J, Simell O, Peet A, Tillmann V, Lamberg-Allardt C, Virtanen S M, Knip M, Vaarala O
Abstract excerpt
BACKGROUND: Vitamin D has immunomodulatory properties, such as regulation of FOXP3 expression and regulatory T-cell activity. Our aim was to investigate whether plasma 25-hydroxyvitamin D [25(OH)D] concentrations associate with the development of β-cell autoimmunity and the transcriptional activity of FOXP3 or vitamin D3 convertase gene (CYP27B1) in CD4+ memory T cells. METHODS: We studied 83 Finnish and 32...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.