Article
Multiple imputation of missing phenotype data for QTL mapping.
Statistical applications in genetics and molecular biology - 1 Jan 2011
Bobb Jennifer F, Scharfstein Daniel O, Daniels Michael J, Collins Francis S, Kelada Samir
Abstract excerpt
Missing phenotype data can be a major hurdle to mapping quantitative trait loci (QTL).Though in many cases experiments may be designed to minimize the occurrence of missing data,it is often unavoidable in practice; thus, statistical methods to account for missing data are needed.In this paper we describe an approach for conjoining multiple imputation and QTL mapping.Methods are applied to map genes associated...
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