Article
Mild expression differences of MECP2 influencing aggressive social behavior.
EMBO molecular medicine - 1 May 2014
Tantra Martesa, Hammer Christian, Kästner Anne, Dahm Liane, Begemann Martin, Bodda Chiranjeevi, Hammerschmidt Kurt, Giegling Ina, Stepniak Beata, Castillo Venzor Aracely, Konte Bettina, Erbaba Begun, Hartmann Annette, Tarami Asieh, Schulz-Schaeffer Walter, Rujescu Dan, Mannan Ashraf U, Ehrenreich Hannelore
Abstract excerpt
The X-chromosomal MECP2/Mecp2 gene encodes methyl-CpG-binding protein 2, a transcriptional activator and repressor regulating many other genes. We discovered in male FVB/N mice that mild (~50%) transgenic overexpression of Mecp2 enhances aggression. Surprisingly, when the same transgene was expressed in C57BL/6N mice, transgenics showed reduced aggression and social interaction. This suggests that Mecp2 modulates...
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