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RNAscope for <em>In situ</em> Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

11 Mar 2014

Abstract excerpt

The 'gold standard' for oncogenic HPV detection is the demonstration of transcriptionally active high-risk HPV in tumor tissue. However, detection of E6/E7 mRNA by quantitative reverse transcription polymerase chain reaction (qRT-PCR) requires RNA extraction which destroys the tumor tissue context critical for morphological correlation and has been difficult to be adopted in routine clinical practice. Our...

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PMID: 24637627
DOI: 10.3791/51426

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