Article
PAX2 polymorphisms and congenital abnormalities of the kidney and urinary tract in a Brazilian pediatric population: evidence for a role in vesicoureteral reflux.
Molecular diagnosis & therapy - 1 Aug 2014
de Miranda Débora Marques, Dos Santos Júnior Augusto César Soares, Dos Reis Geisilaine Soares, Freitas Izabella Silva, Carvalho Thiago Guimarães Rosa, de Marco Luiz Armando Cunha, Oliveira Eduardo Araújo, Simões E Silva Ana Cristina
Abstract excerpt
BACKGROUND AND OBJECTIVES: Congenital anomalies of the kidney and urinary tract (CAKUT) are common genetic malformations. Since the PAX2 gene has a role in kidney organogenesis, this study investigated the association of PAX2 gene polymorphisms with CAKUT in general and with specific phenotypes of CAKUT in a Brazilian pediatric population. METHODS: This study included 241 individuals with antenatal hydronephrosis...
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