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Article

HPV E6/E7 RNA in situ hybridization signal patterns as biomarkers of three-tier cervical intraepithelial neoplasia grade.

PloS one - 1 Jan 2014

Evans Mark F, Peng Zhihua, Clark Kelli M, Adamson Christine S-C, Ma Xiao-Jun, Wu Xingyong, Wang Hongwei, Luo Yuling, Cooper Kumarasen

Abstract excerpt

Cervical lesion grading is critical for effective patient management. A three-tier classification (cervical intraepithelial neoplasia [CIN] grade 1, 2 or 3) based on H&E slide review is widely used. However, for reasons of considerable inter-observer variation in CIN grade assignment and for want of a biomarker validating a three-fold stratification, CAP-ASCCP LAST consensus guidelines recommend a two-tier...

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Share to Cyclin-Dependent Kinase Inhibitor p16
Share to Genes, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization

Share to Oncogene Proteins, Viral

Share to Papillomaviridae

Share to Papillomavirus Infections

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Share to Uterine Cervical Dysplasia

Source

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Identifiers

PMID: 24625757
DOI: 10.1371/journal.pone.0091142
PMCID: PMC3953338

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CISH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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