Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer.

The Journal of pathology - 1 Jul 2014

Liu Guoyan, Sun Yan, Ji Ping, Li Xia, Cogdell David, Yang Da, Parker Kerrigan Brittany C, Shmulevich Ilya, Chen Kexin, Sood Anil K, Xue Fengxia, Zhang Wei

Abstract excerpt

Ovarian carcinoma is the most lethal gynaecological malignancy. Better understanding of the molecular pathogenesis of this disease and effective targeted therapies are needed to improve patient outcomes. MicroRNAs play important roles in cancer progression and have the potential for use as either therapeutic agents or targets. Studies in other cancers have suggested that miR-506 has anti-tumour activity, but its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Cyclin-Dependent Kinase 4

Share to Cyclin-Dependent Kinase 6

Share to Forkhead Transcription Factors

Share to Neoplasms, Cystic, Mucinous, and Serous

Share to Ovarian Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 24604117
DOI: 10.1002/path.4348
PMCID: PMC4144705

Genes

CDK4
FOXM1
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer.PMID 24604117Read ↗

MicroRNA-200c and microRNA-31 regulate proliferation, colony formation, migration and invasion in serous ovarian cancerSemantic proximity Read ↗

MicroRNA-490-3P targets CDK1 and inhibits ovarian epithelial carcinoma tumorigenesis and progression.Semantic proximity Read ↗

Deciphering the role of miR-506 in ovarian cancer drug sensitivitySemantic proximity Read ↗

miR-6850 Drives Phenotypic Changes and Signaling in High Grade Serous Ovarian CancerSemantic proximity Read ↗

miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6Semantic proximity Read ↗

MicroRNA-200 and microRNA-30 family as prognostic molecular signatures in ovarian cancerSemantic proximity Read ↗

CUL4A functions as an oncogene in ovarian cancer and is directly regulated by miR-494.Semantic proximity Read ↗

Dysregulation of miR-375/AEG-1 Axis by Human Papillomavirus 16/18-E6/E7 Promotes Cellular Proliferation, Migration, and Invasion in Cervical CancerSemantic proximity Read ↗

Targeting oncogenic microRNAs in malignant germ cell tumoursSemantic proximity Read ↗

MicroRNA-495 inhibits proliferation of glioblastoma multiforme cells by downregulating cyclin-dependent kinase 6Semantic proximity Read ↗

Targeting CDK6 in cancer: State of the art and new insightsSemantic proximity Read ↗

Upregulated LINC00565 Accelerates Ovarian Cancer Progression By Targeting GAS6Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.