Article
[Molecular profiling of non-small cell lung cancer].
Revue de pneumologie clinique - 1 Jan 2000
Gibault L, Cazes A, Narjoz C, Blons H
Abstract excerpt
The management of locally advanced and metastatic non-small cell lung cancer has been revolutionized thanks to recent progress in pathology and molecular biology. The first molecular subgroup is defined by activating mutations of the epidermal growth factor receptor (EGFR), and a dramatic response to specific tyrosine kinase inhibitors. Since then, multiple genetic alterations (KRAS, HER2, BRAF, PIK3CA, ALK, ROS,...
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