Article
Cancer biomarker discovery: current status and future perspectives.
International journal of radiation biology - 1 Aug 2014
Mäbert Katrin, Cojoc Monica, Peitzsch Claudia, Kurth Ina, Souchelnytskyi Serhiy, Dubrovska Anna
Abstract excerpt
PURPOSE: Cancer is a multigene disease which arises as a result of mutational and epigenetic changes coupled with activation of complex signaling networks. The use of biomarkers for early cancer detection, staging and individualization of therapy might improve patient care. A few fundamental issues such as tumor heterogeneity, a highly dynamic nature of the intrinsic and extrinsic determinants of radio- and...
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