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Article

A global profile of gene promoter methylation in treatment-naïve urothelial cancer

12 Feb 2014

Abstract excerpt

The epigenetic alteration of aberrant hypermethylation in the promoter CpG island of a gene is associated with repression of transcription. In neoplastic cells, aberrant hypermethylation is well described as a mechanism of allele inactivation of particular genes with a tumor suppressor function. To investigate the role of aberrant hypermethylation in the biology and progression of urothelial cancer, we examined...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 24521710
DOI: 10.4161/epi.28078

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